New research reveals that people who discontinue new weight-loss injections like Wegovy and Mounjaro can put back on lost weight at a significantly accelerated pace than those who stop conventional diet and exercise plans.
Published data in a major medical journal points out that while obese individuals often shed about a fifth of their body weight while on the medication, the weight comes back at an estimated rate of 0.8 kg per month after stopping.
"People buying these drugs need to be cognizant of the potential of fast rebound weight gain when the therapy concludes," cautioned expert Dr. Susan Jebb.
Such speed of recovery suggests a return to original mass within about one and a half years.
Comparing Approaches
The study, which looked at dozens of studies involving over 9,000 of patients, contrasted the outcomes of GLP-1 agonists with other pills.
Researchers point out that people who shed pounds through diet and exercise usually have a slower weight regain—approximately 0.1 kg a month—post-intervention.
Understanding the Quick Regain
Nutrition scientists propose the mechanism of the drugs explains the accelerated rebound.
These medications copy a natural hormone called GLP-1, which helps regulate feelings of fullness.
"Sustained high doses of GLP-1 levels several times higher than the body's typical production might result in the system to produce less of its endogenous hormone, and may also diminish responsiveness to its effects," noted Dr. Adam Collins, a dietetics expert.
"Discontinuation of this medication means appetite is unsuppressed, making overeating far more likely."
A Lifelong Condition?
Health authorities recommend the injections for people with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
A number of clinicians argue that, due to the high risk of relapse, the treatment is often ongoing.
This perspective is supported by pharmaceutical companies, who state that the results "underscore the long-term character of excess weight," similar to managing conditions like high blood pressure.
Patient Experiences
Users who have discontinued the jabs explain a powerful resurgence of cravings.
"It was like a switch flipping and I was suddenly extremely hungry," described one woman.
The struggle is compounded if users have not established sustainable lifestyle or habit modifications during treatment.
Growing Use
Survey data suggest that a significant number of people in the UK have used weight-loss jabs in the past year, with demand being substantial.
- Adoption is higher among women compared to males.
- The 40s and 50s age group shows the greatest usage rates.
- Many obtain the medications through private prescriptions rather than public health services.
Finally, clinicians stress that while these medications are potent tools for shedding pounds, they are not a permanent solution and maintained weight loss relies on integrated lifestyle support.
